TRISAID-P

Relief that Moves with You — Fast, Effective & Well-Tolerated.

20x10 Tablets

Pharma

Pain Relief

Product highlights

Dual-mechanism action: Anti-inflammatory (Aceclofenac) + Central & peripheral analgesia (Paracetamol)
Faster onset of pain relief compared to individual components alone
Superior analgesic efficacy with lower individual drug doses — better GI tolerability
Broad-spectrum pain coverage: musculoskeletal, dental, post-operative, and fever
Aceclofenac preferentially inhibits COX-2 — reduced gastric side effects vs traditional NSAIDs
Paracetamol provides safe central analgesic and antipyretic effect
Well-tolerated combination with proven clinical safety profile
Convenient fixed-dose combination for improved patient compliance

TRISAID-P is a fixed-dose combination tablet containing Aceclofenac 100 mg and Paracetamol 325 mg. It combines the potent anti-inflammatory and analgesic activity of Aceclofenac (a selective COX-2 inhibitor NSAID) with the safe central and peripheral analgesic and antipyretic properties of Paracetamol. This synergistic combination provides rapid, effective, and well-tolerated relief from pain and fever across a wide range of clinical conditions, making it a trusted choice in pain management.

Dosage Form

Film-coated Tablets (Oral)

Product Name

TRISAID-P

Composition

Each film-coated tablet contains: Aceclofenac 100 mg + Paracetamol (Acetaminophen) 325 mg

Therapeutic Segment

Analgesics / NSAIDs & Non-opioid Analgesics / Pain Management

Pharmacological Action

Aceclofenac: Preferential COX-2 inhibitor — reduces synthesis of prostaglandins, thereby decreasing inflammation, pain, and fever. Paracetamol: Centrally acting analgesic and antipyretic — inhibits prostaglandin synthesis in the CNS and blocks pain impulse generation peripherally.

Mechanism

Aceclofenac inhibits cyclooxygenase (COX-1 and preferentially COX-2) enzymes, reducing the conversion of arachidonic acid to prostaglandins and thromboxanes, leading to anti-inflammatory and analgesic effects. Paracetamol acts centrally by inhibiting prostaglandin synthesis in the hypothalamus and modulating the endocannabinoid system, producing analgesia and antipyresis without significant anti-inflammatory action at peripheral sites.

Key Clinical Benefits

Synergistic dual-action: anti-inflammatory + analgesic + antipyretic coverage
Faster and more complete pain relief than monotherapy
Preferential COX-2 inhibition by Aceclofenac — reduced GI adverse effects
Paracetamol ensures safe antipyresis and adds central analgesic effect
Lower individual drug doses reduce dose-dependent side effects
Suitable for a broad range of acute and chronic pain conditions
Improved patient compliance with once fixed-dose combination tablet
Well-established safety profile in clinical practice

Key Indications

Rheumatoid Arthritis
Osteoarthritis
Ankylosing Spondylitis
Low back pain & Lumbago
Dental pain & Post-extraction pain
Post-operative pain
Dysmenorrhoea (Painful menstruation)
Musculoskeletal pain & Sports injuries
Fever with pain

Administration

Oral — taken with food or milk to minimize gastric irritation. Swallow whole with adequate water. Avoid lying down for 30 minutes after taking.

Recommended Usage

Adults: 1 tablet (Aceclofenac 100 mg + Paracetamol 325 mg) twice daily (morning and evening) or as directed by the physician. Not recommended in children under 12 years. Duration of use should be as short as possible at the lowest effective dose. Dose adjustment required in elderly patients and those with hepatic/renal impairment.

Dosage Form

Film-coated Tablets (Oral)

Product Name

TRISAID-P

Composition

Each film-coated tablet contains: Aceclofenac 100 mg + Paracetamol (Acetaminophen) 325 mg

Therapeutic Segment

Analgesics / NSAIDs & Non-opioid Analgesics / Pain Management

Pharmacological Action

Analgesics / NSAIDs & Non-opioid Analgesics / Pain Management

Mechanism

Key Clinical Benefits